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A thymocyte-activating factor derived from glomerular mesangial cells.

D H Lovett, J L Ryan, R B Sterzel

    Journal of Immunology (Baltimore, Md. : 1950)
    |April 1, 1983
    PubMed
    Summary
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    Glomerular mesangial cells produce a factor, mesangial cell-derived thymocyte-activating factor (MC-TAF), similar to macrophage interleukin 1. This cytokine may modulate immune responses in glomerular diseases by interacting with the cellular immune system.

    Area of Science:

    • Nephrology
    • Immunology
    • Cell Biology

    Background:

    • The glomerular mesangium plays a key role in immune-mediated glomerulonephritis.
    • Mesangial cells, derived from mesenchyme, share properties with macrophages.

    Purpose of the Study:

    • To investigate the production and function of a factor secreted by cultured rat mesangial cells.
    • To determine if this factor influences immune cell activity.

    Main Methods:

    • Cultured rat mesangial cells were used to identify and characterize secreted factors.
    • Physicochemical properties (heat lability, molecular weight, anion exchange) of the factor were analyzed.
    • The biological activity of the factor on thymocyte proliferation and interleukin 2 production was assessed.

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    Main Results:

    • Cultured mesangial cells produced a factor named mesangial cell-derived thymocyte-activating factor (MC-TAF).
    • MC-TAF exhibited characteristics similar to macrophage interleukin 1 (heat labile, low molecular weight ~15,000, anion exchanger adherence).
    • MC-TAF augmented lectin-induced thymocyte proliferation and enhanced peripheral lymphocyte interleukin 2 production.

    Conclusions:

    • Mesangial cells secrete a cytokine (MC-TAF) with immune-modulating properties.
    • MC-TAF may contribute to immune responses in glomerular diseases through non-specific interactions with the cellular immune system.