Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Peripheral Artery Disease I: Introduction

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...

Peripheral Artery Disease IV: Nursing Management

Peripheral Artery Disease IV: Nursing Management

The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses, temperature changes,...

Peripheral Artery Disease V: Postoperative Nursing Management

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...

Spinal Cord Injury ll: Pathophysiology

Spinal Cord Injury ll: Pathophysiology

Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Spinal cord stimulation.

Spinal cord·2016

Same author

Paroxetine and the electroencephalogram.

Journal of psychopharmacology (Oxford, England)·2011

Same author

Central nervous system regeneration does not occur.

Spinal cord·2011

Same author

On the late failure of spinal cord stimulation for deafferentation pain.

Restorative neurology and neuroscience·2011

Same author

Spina Bifida and an extra lower limb.

Acta neurochirurgica·2008

Same author

Setting the standard--UK neurosurgical acoustic neuroma practice.

Annals of the Royal College of Surgeons of England·2006

Search research articles

Related Experiment Video

Updated: Jul 16, 2026

Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation

Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation

Published on: June 26, 2018

Spinal cord stimulation in peripheral vascular disease.

R C Tallis, L S Illis, E M Sedgwick

Journal of Neurology, Neurosurgery, and Psychiatry

|June 1, 1983

Summary

Spinal cord stimulation improved arterial disease symptoms in six of ten patients, increasing exercise tolerance and blood flow. This treatment offers a promising option for severe, intractable cases.

Area of Science:

Neurology
Vascular Surgery
Pain Management

Background:

Severe arterial disease causes intractable symptoms, significantly impacting quality of life.
Current treatments for severe arterial disease have limitations.
Spinal cord stimulation (SCS) is an emerging therapy for chronic pain and vascular insufficiency.

Purpose of the Study:

To evaluate the efficacy of spinal cord stimulation (SCS) in patients with severe, intractable arterial disease.
To assess the impact of SCS on pain, claudication distance, exercise tolerance, and blood flow.

Main Methods:

Ten patients with severe arterial disease received SCS.
Clinical improvement, rest pain relief, claudication distance, and exercise tolerance were measured.
Cutaneous and muscle blood flow were assessed.

More Related Videos

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing

Published on: October 20, 2021

Studying the Coding Profiles of Somatic Stimulation on Cardiac-locked Neuronal Responses in the Rat Spinal Dorsal Horn

Studying the Coding Profiles of Somatic Stimulation on Cardiac-locked Neuronal Responses in the Rat Spinal Dorsal Horn

Published on: May 23, 2025

Related Experiment Videos

Last Updated: Jul 16, 2026

Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation

Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation

Published on: June 26, 2018

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing

Published on: October 20, 2021

Studying the Coding Profiles of Somatic Stimulation on Cardiac-locked Neuronal Responses in the Rat Spinal Dorsal Horn

Studying the Coding Profiles of Somatic Stimulation on Cardiac-locked Neuronal Responses in the Rat Spinal Dorsal Horn

Published on: May 23, 2025

Transcutaneous (placebo) stimulation was used as a control.

Main Results:

Six out of ten patients showed clinical improvement with SCS.
Significant increases in mean claudication distance (65m to 212m) and exercise tolerance (61%) were observed.
Improvements were maintained during continuous SCS and were not attributed to placebo effects.

Conclusions:

Spinal cord stimulation is an effective treatment for severe, intractable arterial disease.
SCS likely works through antidromic sensory neuron stimulation, possibly involving prostaglandin release.
Further research is warranted to elucidate the precise mechanisms of action.