Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hyperthermia as a possible teratogenic agent.

D W Smith, S K Clarren, M A Harvey

    The Journal of Pediatrics
    |June 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Cancer mortality at very old ages.

    Cancer·1996
    Same author

    Racial differences on psychological measures in combat veterans seeking treatment for PTSD.

    Journal of personality assessment·1996
    Same author

    Mosquito-borne viruses and epidemic polyarthritis.

    The Medical journal of Australia·1996
    Same author

    Consensus phylogeny of Dictyostelium.

    Experientia·1995
    Same author

    Role of ventrolateral medulla catecholamine cells in hypothalamic neuroendocrine cell responses to systemic hypoxia.

    The Journal of neuroscience : the official journal of the Society for Neuroscience·1995
    Same author

    Venous catheter thrombus formation and pulmonary embolism in children.

    Pediatric pulmonology·1995

    Maternal hyperthermia during early pregnancy may cause developmental problems in infants. High fever in early gestation is linked to severe birth defects, including mental deficiency and physical abnormalities.

    Area of Science:

    • Developmental Biology
    • Teratology
    • Human Genetics

    Background:

    • Hyperthermia is a known teratogen in animal models.
    • The effects of maternal fever on human embryonic and fetal development require further investigation.

    Purpose of the Study:

    • To investigate the potential teratogenic effects of maternal hyperthermia during early human gestation.
    • To identify specific developmental abnormalities associated with maternal fever during different gestational periods.

    Main Methods:

    • Retrospective case series analysis of infants born after maternal high fever during pregnancy.
    • Clinical phenotyping of infants to identify consistent manifestations.
    • Correlation of maternal fever timing with observed developmental outcomes.

    Related Experiment Videos

    Main Results:

    • Maternal hyperthermia at 4-6 weeks gestation was associated with severe mental deficiency, seizures, hypotonia, microphthalmia, midface hypoplasia, and limb development issues.
    • Exposure at 7-16 weeks gestation resulted in hypotonia, neurogenic arthrogryposis, and central nervous system dysgenesis.
    • Hyperthermia in the latter half of gestation did not appear to cause significant morphogenesis problems.

    Conclusions:

    • Maternal hyperthermia during early to mid-gestation poses a significant risk for human developmental abnormalities.
    • The observed phenotypes are consistent with animal studies on hyperthermia-induced teratogenesis.
    • Further research is warranted to understand the full impact of hyperthermia on human development.