Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cloprednol bioavailability in humans.

E J Mroszczak, R Runkel, L J Strand

    Journal of Pharmaceutical Sciences
    |July 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Montezuma's banquet: conjectures of a field anthropologist on systems of classification and social structure in 16th-century Mexico].

    Relaciones (Colegio de Michoacan)·2011
    Same author

    The transuranium elements.

    Nature·2010
    Same author

    Boron trifluoride neutron detector for low neutron intensities.

    The Review of scientific instruments·2010
    Same author

    Dynamics of a vesicle in general flow.

    Proceedings of the National Academy of Sciences of the United States of America·2009
    Same author

    Complex refractive indices of aerosols retrieved by continuous wave-cavity ring down aerosol spectrometer.

    Analytical chemistry·2009
    Same author

    Photoluminescence ring formation in coupled quantum wells: excitonic versus ambipolar diffusion.

    Physical review letters·2008
    Same journal

    Green, renewable, or low-carbon? A framework for informed solvent selection in pharmaceutical sciences.

    Journal of pharmaceutical sciences·2026
    Same journal

    Theranostic potential of ramucirumab functionalized magnetoliposomes for targeted delivery of sorafenib and MRI.

    Journal of pharmaceutical sciences·2026
    Same journal

    Intranasal mucoadhesive chitosan microspheres of ranolazine: Formulation, design, and pharmacokinetic evaluation.

    Journal of pharmaceutical sciences·2026
    Same journal

    Evolving landscape of drug development for pediatric rare diseases-from successes to strategies for addressing unmet needs.

    Journal of pharmaceutical sciences·2026
    Same journal

    A mathematical framework for predicting tablet weight variability from blend particle size distribution and tooling geometry.

    Journal of pharmaceutical sciences·2026
    Same journal

    Recrystallization can stop nitrosamine formation in ranitidine hydrochloride.

    Journal of pharmaceutical sciences·2026
    See all related articles

    Cloprednol, a new systemic corticosteroid, showed complete bioavailability across all tested formulations. Solid dose forms demonstrated bioequivalence, while the solution offered faster absorption but equivalent overall bioavailability.

    Area of Science:

    • Pharmacokinetics
    • Drug bioavailability
    • Corticosteroid research

    Background:

    • Cloprednol is a novel systemic corticosteroid.
    • Understanding its bioavailability is crucial for therapeutic efficacy.
    • Formulation can impact drug absorption and delivery.

    Purpose of the Study:

    • To evaluate the bioavailability of cloprednol from different oral formulations.
    • To compare the rate and extent of cloprednol absorption.
    • To assess the bioequivalence of capsules, a tablet, and a solution.

    Main Methods:

    • A 12-subject crossover study design was employed.
    • Plasma cloprednol concentrations were measured using GLC-mass spectrometry.
    • Key pharmacokinetic parameters including half-life, peak concentration, and area under the curve were analyzed.

    Related Experiment Videos

    Main Results:

    • Cloprednol exhibited rapid plasma clearance with a half-life of 1.86 ± 0.36 hours.
    • All formulations demonstrated complete and equivalent extent of cloprednol absorption.
    • Solid dosage forms (capsules, tablet) were bioequivalent in rate and extent; the solution showed faster absorption but equal overall bioavailability.

    Conclusions:

    • Cloprednol is completely bioavailable from capsules, a tablet, and a solution.
    • Solid oral formulations of cloprednol are bioequivalent.
    • The formulation impacts absorption rate but not the total extent of cloprednol bioavailability.