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Related Experiment Videos

Multiple sclerosis after age 50.

J Noseworthy, D Paty, T Wonnacott

    Neurology
    |December 1, 1983
    PubMed
    Summary
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    Late-onset multiple sclerosis (MS) in patients over 50 presents diagnostic challenges. This group experienced slower motor function decline but faster disability progression, suggesting a revised age-onset criterion for MS.

    Area of Science:

    • Neurology
    • Clinical Medicine

    Background:

    • Late-onset multiple sclerosis (MS), presenting after age 50, poses diagnostic challenges.
    • Approximately 9.4% of patients in a large MS clinic population exhibited late-onset MS.

    Purpose of the Study:

    • To investigate the clinical characteristics and diagnostic yield of investigations in late-onset MS patients.
    • To evaluate the suitability of the current age-of-onset criterion for MS.

    Main Methods:

    • Analysis of a large multiple sclerosis (MS) clinic population (N = 838).
    • Review of initial symptoms, clinical course, and diagnostic test results (evoked response studies, CSF electrophoresis) in older patients.

    Main Results:

    • Late-onset MS patients (onset >50 years) showed slow initial motor deterioration but more rapid disability progression compared to younger patients.

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  • Evoked response studies and CSF electrophoresis demonstrated high diagnostic utility in this older patient cohort.

    • Conclusions:

    • Late-onset MS exhibits distinct clinical features and progression patterns.
    • The findings support reconsidering the age-of-onset criterion for MS, potentially raising it to 60 years in well-investigated cases.