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Dialkylformamidines: depurination resistant N6-protecting group for deoxyadenosine

B C Froehler, M D Matteucci

Nucleic Acids Research

|November 25, 1983

Abstract:

Sterically hindered N6-dialkylformamidine protected deoxyadenosine is more stable to acidic depurination than N6-benzoyldeoxyadenosine and is potentially a valuable protecting group in the synthesis of deoxyoligonucleotides.

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