[Effect of Faustan (diazepam) on the normal and myotonically reacting frog skeletal muscle]

The antimyotonic effect of Faustan (diazepam) was investigated in the experimentally induced myotonia by 2,4-dichlorophenoxyacetate (2,4-D). The results show that Faustan does not improve the myotonic phenomena. Neither was the fall in membrane potential prevented nor were the myotonic muscle fiber changes of 2,4-D and had in its turn a depressive influence on the muscle. Depending on the concentration the drug developed a more depressive effect on the mechanical reaction than the electrical activity. These findings are compared with the results described in the relevant literature and are discussed in connection with the inhibition of electro-mechanical coupling.