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Enteric bacteria and HLA-B27 associated cell surface modification in patients with seronegative spondarthritis
British Journal of Rheumatology
|November 1, 1983
Abstract:
Cytotoxic studies indicate cross-reactivity between some enteric organisms and cells obtained from the majority of patients with ankylosing spondylitis. Preliminary studies suggest that the factor responsible for cross-reactivity may be generated by a bacterial plasmid. However, the mechanism mediating the interaction between the HLA-B27 positive cell and the bacterial antigen is at present unknown.
Insights
Cytotoxic studies reveal cross-reactivity between enteric organisms and cells from ankylosing spondylitis patients. A bacterial plasmid may generate this factor, but the interaction mechanism with HLA-B27 positive cells remains unclear.
Area of Science:
- Immunology
- Microbiology
- Genetics
Background:
- Ankylosing spondylitis (AS) is a chronic inflammatory disease often associated with HLA-B27.
- A potential link exists between gut microbiota and AS pathogenesis.
- Cross-reactivity between enteric organisms and host cells is implicated in AS.
Purpose of the Study:
- To investigate the cytotoxic cross-reactivity between enteric organisms and patient-derived cells in ankylosing spondylitis.
- To explore the potential role of bacterial plasmids in mediating this cross-reactivity.
- To identify the unknown mechanism of interaction between HLA-B27 positive cells and bacterial antigens.
Main Methods:
- Cytotoxic assays were performed using enteric organisms and cells from ankylosing spondylitis patients.
- Preliminary investigations explored the involvement of bacterial plasmids.
- Further studies aimed to elucidate the interaction mechanism.
Main Results:
- Cytotoxic cross-reactivity was observed between certain enteric organisms and cells from most ankylosing spondylitis patients.
- Preliminary data suggest a bacterial plasmid may be responsible for generating the cross-reactive factor.
- The precise mechanism of interaction between HLA-B27 positive cells and bacterial antigens is currently unknown.
Conclusions:
- Enteric organisms exhibit cross-reactivity with cells from ankylosing spondylitis patients, suggesting an immune-mediated connection.
- Bacterial plasmids are a potential source of the factor causing this cross-reactivity.
- Further research is required to understand the molecular mechanisms underlying the interaction between bacterial antigens and HLA-B27.