Related Experiment Video
Updated: Jul 26, 2026

08:35
A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice
Published on: March 17, 2015
Differences in thermal responses of cat trigeminal ganglion 'cold' receptors under urethane and pentobarbital
Brain Research
|February 6, 1984
Abstract:
Cutaneous thermoreceptors recorded from the trigeminal ganglion of cats anesthetized with urethane showed a significant reduction in thermal sensitivity when compared with neuronal responses obtained from sodium pentobarbital-anesthetized cats. The results of this study indicate that a detailed analysis of primary afferent thermoreceptor response characteristics should consider the anesthesia employed.
More Related Videos
Related Concept Videos
Thermosensation
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
Local Anesthetics: Differential Sensitivity of Nerve Fibers
Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...

