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Chromosome 4 Jt gene controls murine T cell surface I-J expression
Science (New York, N.Y.)
|February 10, 1984
Summary
This study resolves the I-J paradox by showing suppressor T cell marker expression involves two genes. One gene is on chromosome 17, and a new gene, Jt, is on chromosome 4.
Area of Science:
- Immunogenetics
- Molecular Biology
- T cell immunology
Background:
- The murine response subregion I-J encodes a suppressor T cell marker.
- A paradox exists as I-J DNA sequences were not found in the expected immune response region.
Purpose of the Study:
- To resolve the paradox of I-J subregion definition.
- To elucidate the genetic basis of T cell surface I-J expression.
Main Methods:
- Genetic analysis of recombinant mouse strains.
- Investigating gene complementation for I-J expression.
Main Results:
- T cell surface I-J expression is controlled by at least two complementing genes.
- One gene is located within the H-2 region on chromosome 17.
- A second gene, Jt, is identified on chromosome 4.
Conclusions:
- The original definition of the I-J subregion may be flawed.
- The studied mouse strains likely differ at the Jt locus on chromosome 4, not within the H-2 region.