Related Experiment Videos
Glucagon and gastroesophageal reflux
AJR. American Journal of Roentgenology
|April 1, 1984
Summary
Glucagon minimally impacts spontaneous gastroesophageal reflux (GER) in healthy individuals. Radionuclide studies showed GER occurred in only 8% of volunteers after glucagon, indicating most remain asymptomatic.
Area of Science:
- Gastroenterology
- Nuclear Medicine
Background:
- Gastroesophageal reflux (GER) is a common condition.
- The role of glucagon in GER is not fully understood.
Purpose of the Study:
- To investigate the effect of glucagon on spontaneous gastroesophageal reflux in healthy volunteers.
Main Methods:
- Utilized radionuclide gastroesophageal reflux techniques.
- 24 asymptomatic volunteers served as their own controls.
- Assessed GER before and after 1 mg glucagon administration.
Main Results:
- No spontaneous GER observed before glucagon.
- GER occurred in 8% (2/24) of volunteers post-glucagon.
- No GER observed during simulated double-contrast upper GI examination.
Conclusions:
- Glucagon may facilitate GER in a small percentage of normal individuals.
- Most healthy individuals do not experience spontaneous GER, even after glucagon administration.