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Open-angle glaucoma associated with posterior polymorphous dystrophy. A clinicopathologic study.

J Bourgeois, M B Shields, R Thresher

    Ophthalmology
    |April 1, 1984
    PubMed
    Summary
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    Posterior polymorphous dystrophy (PPMD) can be associated with a developmental anomaly causing open-angle glaucoma. This glaucoma involves high iris insertion into the trabecular meshwork, compressing drainage spaces.

    Area of Science:

    • Ophthalmology
    • Histopathology
    • Genetics

    Background:

    • Posterior polymorphous dystrophy (PPMD) is a rare inherited eye condition.
    • Open-angle glaucoma is a common form of glaucoma often treated with surgery.
    • Trabeculectomy is a surgical procedure to lower intraocular pressure.

    Observation:

    • A 62-year-old man with PPMD and open-angle glaucoma underwent a modified trabeculectomy.
    • The surgical specimen included deep limbal tissue and peripheral iris.
    • Microscopic examination revealed high iris insertion into the posterior trabecular meshwork.

    Findings:

    • The iris insertion compressed the intertrabecular spaces, obstructing aqueous humor outflow.
    • These histopathologic findings resemble those seen in primary congenital glaucoma.

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  • A developmental anomaly of the anterior chamber angle is suggested in glaucoma associated with PPMD.

    • Implications:

    • This suggests a potential shared developmental pathway between PPMD and certain types of glaucoma.
    • Understanding this association may lead to earlier diagnosis and tailored treatment strategies for affected individuals.
    • Further research into anterior chamber development could elucidate the pathogenesis of both conditions.