Comparison of the radiosensitivity of three goldfish cell lines using short term endpoints

The induction and rejoining of DNA strand breaks after gamma-irradiation in three goldfish (Carassius auratus) cell lines with different sensitivities to the lethal effect of gamma-rays has been studied by the DNA strand separation method using hydroxylapatite chromatography. The induction and rejoining of DNA strand breaks was similar in all cell lines. There was also little difference in the degree of inhibition of DNA synthesis immediately after irradiation. However, the rank orders of the durations of division delay and the radiosensitivities of the three cell lines were the same.