[Therapy of experimental staphylococcal infection by the transfusion of allogeneic leukocytes]

Severe nonlethal generalized staphylococcal infection was induced in guinea pigs by the intramuscular injection of S. aureus. On days 1, 3 and 5 after the infection the animals received intracardiac injections of leukocytes from intact donors. On any day of investigation following the injection of staphylococci (up to day 14) the number of colonies in the spleen of the animals subjected to immunotherapy was considerably lower than that in the spleen of the control animals. The treated animals showed a higher percentage of neutrophils with receptors for Fc-fragments of immunoglobulins and for complement, as well as higher levels of active T- and B-lymphocytes. The data thus obtained correspond to the results of clinical treatment and examination.