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Updated: Aug 3, 2026

Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats
Published on: March 11, 2016
[Kidney function study of healthy persons by the 131I-hippuran renography method under prolonged hypokinesia]
Abstract:
The paper describes renography studies (using I131-hippurane) of the renal function of 28 test subjects who participated in 30- and 120-day bed rest experiments. Typical changes in the vascular, secretory and evacuatory segments of renograms were noted. The delay in the isotope absorption and excretion from the blood and kidneys was mostly expressed by the end of bed rest. A relationship between renographic changes and renal blood flow as well as between renal excretion of water and sodium at different experimental stages was established. The above changes in the renal function were functional and associated with changes in the systems controlling the fluidelectrolyte metabolism.
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