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Plasma lipid transfer in fish-eye disease
Acta Medica Scandinavica
|January 1, 1983
Summary
Fish-eye disease involves abnormal low-density lipoprotein (LDL) composition. This study found normal lipid transfer protein activity, suggesting it
Area of Science:
- Lipid metabolism
- Ophthalmology
- Genetics
Background:
- Fish-eye disease is a rare genetic disorder.
- Characterized by corneal opacities and dyslipoproteinaemia.
- Plasma low-density lipoprotein (LDL) shows triglyceride enrichment.
Purpose of the Study:
- To investigate the role of lipid transfer protein activity in fish-eye disease.
- To determine if a deficiency in this protein contributes to abnormal LDL composition.
Main Methods:
- Assessed cholesterol ester and triglyceride transferase activities.
- Measured activities in lipoprotein-free plasma from two fish-eye disease patients.
Main Results:
- Lipid transferase activities were found to be normal in the patients.
Conclusions:
- A deficiency of plasma lipid transfer protein is not the cause of abnormal LDL composition in fish-eye disease.
- The underlying mechanism for dyslipoproteinaemia in fish-eye disease requires further investigation.