Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nontransmural versus transmural myocardial infarction. A morphologic study.

A G Freifeld, E H Schuster, B H Bulkley

    The American Journal of Medicine
    |September 1, 1983
    PubMed
    Summary

    This study compared nontransmural and transmural myocardial infarcts, finding key differences in prior infarct history and coronary thrombi, suggesting distinct pathophysiologies despite clinical similarities. Recognizing this heterogeneity is crucial for accurate patient prognosis.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    BK Viremia as a Predictor of Hemorrhagic Cystitis in Adults During the First 100 Days After Allogeneic Hematopoietic Stem Cell Transplantation.

    Transplantation proceedings·2018
    Same author

    Endemic fungal infections in solid organ and hematopoietic cell transplant recipients enrolled in the Transplant-Associated Infection Surveillance Network (TRANSNET).

    Transplant infectious disease : an official journal of the Transplantation Society·2014
    Same author

    False-positive Aspergillus galactomannan assay in solid organ transplant recipients with histoplasmosis.

    Transplant infectious disease : an official journal of the Transplantation Society·2011
    Same author

    Seronegative naturally acquired West Nile virus encephalitis in a renal and pancreas transplant recipient.

    Transplant infectious disease : an official journal of the Transplantation Society·2010
    Same author

    Seroprevalence of West Nile virus infection in solid organ transplant recipients.

    Transplant infectious disease : an official journal of the Transplantation Society·2009
    Same author

    Sepsis and solid organ transplantation.

    Current drug targets·2007

    Area of Science:

    • Cardiology
    • Pathology
    • Medical Morphology

    Background:

    • Myocardial infarction classification into "nontransmural" and "transmural" is common but lacks clear clinical course correlation.
    • Morphologic definitions of transmural (full-thickness) and nontransmural (partial-thickness) infarcts require validation regarding clinical and pathological outcomes.

    Purpose of the Study:

    • To identify true nontransmural acute myocardial infarcts at autopsy.
    • To compare nontransmural infarcts with age-matched transmural infarcts for clinical and pathological similarities and differences.

    Main Methods:

    • Autopsy comparison of 35 nontransmural and 35 transmural acute myocardial infarcts.
    • Analysis of clinical data (chest pain, arrhythmias, heart block, dyspnea, Q waves) and pathological findings (heart weight, infarct location, coronary disease severity, infarct age/size, prior infarcts, coronary thrombi, necrosis type).

    Related Experiment Videos

    Main Results:

    • No significant differences in race, sex, chest pain, arrhythmias, heart block, or cause of death.
    • Transmural infarcts showed more new Q waves and increasing dyspnea.
    • Nontransmural infarcts had a higher prevalence of prior infarcts.
    • Acute coronary thrombi were more common in transmural infarcts.
    • Nontransmural infarcts exhibited more contraction band (reflow) injury.

    Conclusions:

    • Fatal nontransmural and transmural infarcts share clinical and pathological similarities.
    • Differences in prior infarcts, necrosis type, and coronary thrombi suggest distinct pathophysiologies.
    • The heterogeneity within both infarct classifications necessitates careful consideration in clinical studies and patient assessment.