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The genetic influence on serum haemolytic complement levels in cattle
Animal Blood Groups and Biochemical Genetics
|January 1, 1983
Summary
Serum haemolytic complement (HC) activity in Norwegian Red Cattle shows significant sire influence. Heritability estimates suggest a strong genetic component, likely involving a few key genes.
Area of Science:
- Animal genetics
- Immunology
- Livestock breeding
Background:
- Serum haemolytic complement (HC) activity is a crucial component of innate immunity.
- Understanding the genetic basis of HC activity can inform breeding strategies for disease resistance in cattle.
Purpose of the Study:
- To determine the total serum haemolytic complement (HC) activity in Norwegian Red Cattle (NRF).
- To estimate the heritability of HC activity and investigate its mode of inheritance.
Main Methods:
- Serum samples were collected from 130 young bulls of the Norwegian Red Cattle Breed.
- Total serum haemolytic complement (HC) activity was measured using standardized assays.
Main Results:
- A highly significant sire effect (p < 0.01) on HC activity was observed.
- Heritability for HC activity was estimated to be approximately 0.75.
- Distribution patterns suggest the influence of a limited number of genes, rather than a simple inheritance mode.
Conclusions:
- Genetic factors, particularly those controlled by sires, play a substantial role in determining serum HC activity in NRF.
- The findings support the potential for selective breeding to modulate HC activity and potentially enhance immune function in cattle.