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Compound action potential input-output decruitment. Effect of topically applied antiseptics
Archives of Otolaryngology (Chicago, Ill. : 1960)
|October 1, 1983
Summary
Povidone-iodine antiseptic caused hearing loss in chinchillas, particularly at higher frequencies. This ototoxic effect impacts auditory nerve function and may affect speech perception.
Area of Science:
- Ototoxicology
- Auditory Neuroscience
- Pharmacology
Background:
- Povidone-iodine is a common topical antiseptic.
- Potential ototoxicity of antiseptics requires investigation.
- Chinchilla model is valuable for auditory research.
Purpose of the Study:
- To evaluate the ototoxic effects of povidone-iodine on the chinchilla auditory system.
- To assess the impact on auditory nerve function, specifically the action potential (AP) input-output function.
Main Methods:
- Topical application of povidone-iodine to the chinchilla round window.
- Measurement of auditory action potential (AP) thresholds and input-output functions at various frequencies (2, 4, 8, 12 kHz).
Main Results:
- Marked elevation in AP threshold at high frequencies (8 and 12 kHz).
- Slight threshold elevation at lower frequencies (2 and 4 kHz).
- Distinct decruitment observed in the AP input-output function at lower frequencies, indicating impaired neural response growth.
Conclusions:
- Povidone-iodine exhibits ototoxic properties in the chinchilla model.
- The observed hearing loss primarily affects high frequencies.
- Implications for speech frequency perception due to ototoxic high-frequency hearing loss.