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The synthesis, bioactivity and enzyme stability of D-Ala2, EPhe4, Leu5-enkephalins
Biochemical and Biophysical Research Communications
|August 30, 1983
Abstract:
We have synthesized the first enkephalin analog containing a "cyclopropyl" phenylalanine (Phe) residue. The E-configuration of this residue is apparently responsible for its low activity in the MVD and GPI muscle assays. The enkephalin is very stable to cleavage by carboxypeptidase Y.