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Related Experiment Videos

A simpler retractable wire knife.

J W Chambers

    Brain Research Bulletin
    |June 1, 1983
    PubMed
    Summary

    Researchers developed an affordable, retractable wire knife for precise neural pathway transections. This tool accurately induced overeating and weight gain in female rats by targeting hypothalamic pathways.

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    Area of Science:

    • Neuroscience
    • Surgical Instrumentation

    Background:

    • Stereotaxic surgery requires precise tools for targeting neural pathways.
    • Existing methods for neural pathway transection can be complex or costly.

    Purpose of the Study:

    • To describe the construction of a simple, inexpensive retractable wire knife and holder/adjuster.
    • To validate the accuracy and reliability of this new surgical instrument.

    Main Methods:

    • Detailed construction of a retractable wire knife and holder/adjuster.
    • Stereotaxic placement of the instrument for neural pathway transections.
    • Experimental validation using bilateral parasagittal hypothalamic knife cuts in female rats.

    Main Results:

    • The constructed knife and holder/adjuster proved to be simple and inexpensive.
    • Experimental data confirmed the accuracy and reliability of the knife.
    • Bilateral parasagittal hypothalamic knife cuts successfully induced excessive food intake and body weight gain.

    Conclusions:

    • The developed retractable wire knife is a viable and cost-effective tool for stereotaxic neural pathway transections.
    • The instrument's reliability is supported by its ability to produce predictable physiological outcomes.
    • This tool facilitates research into hypothalamic functions related to appetite and weight regulation.

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