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Urographic changes in homozygous sickle cell disease
Diagnostic Imaging
|January 1, 1983
Summary
Sickle cell disease significantly impacts Nigerian patients, with high rates of kidney abnormalities like renal papillary necrosis found in urographic studies. These findings highlight the critical need for monitoring kidney health in sickle cell patients.
Area of Science:
- Nephrology
- Hematology
- Radiology
Background:
- Sickle cell disease (SCD) is a genetic blood disorder prevalent in Nigeria.
- Kidney complications are a significant concern in SCD patients.
- Urographic studies are essential for assessing renal function and structure.
Purpose of the Study:
- To investigate the prevalence and types of urographic abnormalities in Nigerian patients with homozygous sickle cell disease.
- To determine the relationship between urographic findings, age, sex, and urinary symptoms.
Main Methods:
- A prospective urographic study was conducted on 40 Nigerian patients with homozygous sickle cell disease.
- Patients' ages ranged from 13 to 51 years, with a mean age of 20.
- Excretory urograms were analyzed for various renal abnormalities.
Main Results:
- 30% of patients had normal excretory urograms.
- High incidence of renal papillary necrosis (40%) and non-obstructive caliectasis (47.5%) observed.
- Poor contrast excretion (40%) and renal enlargement were also noted; no age, sex, or symptom correlation found.
Conclusions:
- Homozygous sickle cell disease is associated with a high burden of urographic abnormalities in Nigerian patients.
- Renal papillary necrosis and non-obstructive caliectasis are common findings.
- Routine urographic screening may be beneficial for early detection of kidney damage in SCD patients.