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Evidence for dopamine-containing renal nerves.

R J Dinerstein, R T Jones, L I Goldberg

    Federation Proceedings
    |October 1, 1983
    PubMed
    Summary

    Researchers found evidence of dopaminergic innervation in the kidney, supporting the existence of a prejunctional dopamine (DA) receptor counterpart to the renal DA1 postsynaptic receptor.

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    Area of Science:

    • Nephrology
    • Neuroscience
    • Pharmacology

    Background:

    • The renal DA1 postsynaptic receptor for dopamine (DA) is well-established.
    • The existence of a corresponding dopaminergic innervation in the kidney has been hypothesized.
    • Dopamine plays a role in renal function, alongside norepinephrine (NE).

    Purpose of the Study:

    • To investigate the presence and function of dopaminergic innervation in the kidney.
    • To identify a potential prejunctional dopaminergic counterpart to the renal DA1 receptor.

    Main Methods:

    • Analysis of dopamine (DA) and norepinephrine (NE) levels in canine and rat kidneys.
    • Assessment of NE and DA secretion following renal stimulation and denervation.
    • Histological examination to identify dopaminergic neuronal elements in the kidney.

    Main Results:

    • Canine kidneys show a higher proportion of DA relative to NE.
    • Chronic denervation resulted in the loss of both NE and DA.
    • Renal stimulation increased NE and DA secretion; denervation eliminated NE but only partially reduced DA secretion, suggesting a non-NE-dependent DA release.
    • Histological techniques confirmed the presence of DA-containing neuronal elements within the kidney.

    Conclusions:

    • There is substantial evidence supporting the existence of dopaminergic innervation in the kidney.
    • These findings suggest a prejunctional dopaminergic system that complements the postsynaptic DA1 receptor.
    • This dopaminergic innervation likely plays a functional role in renal physiology.

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