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Effect of cefoperazone on faecal flora.
The Journal of Antimicrobial Chemotherapy
|August 1, 1983
Summary
Cefoperazone significantly altered intestinal flora, suppressing many beneficial bacteria and increasing harmful ones. This disruption, including Clostridium difficile emergence, may lead to clinical issues.
Area of Science:
- Microbiology
- Pharmacology
- Gastroenterology
Background:
- Antibiotic therapy can profoundly impact the gut microbiome.
- Understanding the specific effects of cefoperazone on intestinal flora is crucial for patient care.
Purpose of the Study:
- To investigate the impact of cefoperazone on the quantitative composition of aerobic and anaerobic intestinal micro-organisms.
- To assess the clinical relevance of observed alterations in gut flora.
Main Methods:
- Quantitative fecal culture analysis of aerobic and anaerobic microorganisms.
- Study involved 29 patients treated with cefoperazone for 7-14 days.
- Specimens collected before, during, and after antibiotic therapy.
Main Results:
- Cefoperazone markedly suppressed key bacteria including enterobacteria, staphylococci, and lactobacilli.
- Enterococci counts increased in most patients; clostridia remained stable.
- Clostridium difficile was detected in 8 patients during or post-treatment.
Conclusions:
- Cefoperazone administration causes significant dysbiosis of the intestinal microbiota.
- The observed alterations, particularly the rise of Clostridium difficile, may have significant clinical implications.