Related Experiment Video
Updated: Aug 8, 2026

Improving IV Insulin Administration in a Community Hospital
Published on: June 11, 2012
Evidence for hyperglycemic osmotic matrix effects on the Comprehensive Hematology Survey 1981-1982
Abstract:
Several authors have suggested that a plausible mechanism for variation in reported mean corpuscular volume (MCV) and hematocrit values for Hematology Survey Specimens may be due to the presence of hyperglycemia in the suspending matrix of the specimens, resulting in cell swelling due to an osmotic matrix effect. The Hematology Resource Committee of the College of American Pathologists has examined this question prospectively and concludes, although there is evidence for an osmotic matrix effect, such an effect is insufficient to explain all the variation in MCV seen between different specimens analyzed. An instrument dependent analytic variation is present in addition to an osmotic matrix effect and appears intrinsic to the instrument systems studied. The probability that such an effect can be eliminated in preparation of an external proficiency testing program specimen is small.
More Related Videos
07:22Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
Published on: March 7, 2025
14:10A Microfluidic System for Modeling Endothelial Dysfunction under Combined Physiological Pulsatile Shear Stress and Oscillatory Hyperglycemia
Published on: May 12, 2026
Related Concept Videos
Diabetes: Symptoms, Diagnosis, and Complications
Type I Diabetes III: Clinical Manifestations
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis
Hyperglycemia
Hyperosmolar Hyperglycemic State