Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Genetic and evolutionary implications in peptic ulcer disease.

G M Petersen, J I Rotter

American Journal of Physical Anthropology

|September 1, 1983

Summary

Genetic factors influence peptic ulcer disease. Elevated serum pepsinogen I (PG I) levels indicate a subgroup of patients with autosomal dominant inheritance, linked to gastric hyperacidity and ulcer pathogenesis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The age-dependent association of risk factors with pancreatic cancer.

Annals of oncology : official journal of the European Society for Medical Oncology·2022

Same author

Genome-wide analysis of mitochondrial DNA copy number reveals loci implicated in nucleotide metabolism, platelet activation, and megakaryocyte proliferation.

Human genetics·2021

Same author

Reply to Are cohort data on smokeless tobacco use and pancreatic cancer confounded by alcohol use?

Annals of oncology : official journal of the European Society for Medical Oncology·2020

Same author

Genome-wide meta-analysis of variant-by-diuretic interactions as modulators of lipid traits in persons of European and African ancestry.

The pharmacogenomics journal·2019

Same author

Bidirectional Mendelian randomization to explore the causal relationships between body mass index and polycystic ovary syndrome.

Human reproduction (Oxford, England)·2018

Same author

Pharmacogenomics study of thiazide diuretics and QT interval in multi-ethnic populations: the cohorts for heart and aging research in genomic epidemiology.

The pharmacogenomics journal·2017

Area of Science:

Genetics
Gastroenterology
Human Physiology

Background:

Peptic ulcer disease (PUD) has long been suspected to have a genetic basis, with early evidence from twin, family, and blood group studies.
Previous polygenic inheritance models for PUD have been challenged by evidence supporting genetic heterogeneity.

Purpose of the Study:

To investigate the role of subclinical genetic markers in identifying distinct subgroups within peptic ulcer disease patients.
To examine the inheritance pattern of elevated serum pepsinogen I (PG I) levels in relation to duodenal ulcer disease.

Main Methods:

Analysis of familial aggregation of elevated serum pepsinogen I (PG I) levels in sibling groups (sibships) of duodenal ulcer patients.
Correlation of elevated PG I levels with gastric hyperacidity and potential indicators of increased gastric cell mass.

Main Results:

Elevated serum pepsinogen I (PG I) levels are associated with a specific subgroup of duodenal ulcer patients.
Segregation analysis of elevated PG I in duodenal ulcer sibships suggests autosomal dominant inheritance.
Elevated PG I is linked to gastric hyperacidity, indicating individuals with increased chief and parietal cell mass and higher peptic activity.

Conclusions:

Serum pepsinogen I (PG I) serves as a valuable marker for a genetically distinct subgroup of duodenal ulcer patients.
The findings support a genetic heterogeneity model for peptic ulcer disease, with autosomal dominant inheritance playing a role in certain cases.
An evolutionary hypothesis suggests selection for increased peptic activity and gastric acidity may explain the genetic and epidemiologic features of this ulcer subgroup.

Related Experiment Videos