[Changes in the skeletal muscles during experimental ischemia of the extremity]

Histochemical and morphological changes in the tibial and calf muscles of the forelimbs were studied in dogs 3 months after experimentally induced ischemia of varying severity. In moderate ischemia, the activity of oxidation-reduction enzymes increases, that of adenozine triphosphatase decreases. The diameter of muscle fibers increases. These changes are considered to be compensatory. Severe ischemia is accompanied by suppressed activity of succinate dehydrogenase, myofibril damage, and formation of centres of ischemic dystrophy.