[Crohn disease associated with Turner's syndrome (a possible physiopathological mechanism)]

We describe a patient with Turner's syndrome who has developed chronic diarrhea, anal fissures, rectovaginal and perianal fistulas. Radiological study of the ileum and rectal mucosa biopsy have confirmed the diagnosis of Crohn's disease. Like the majority of patients previously described with similar pathological association, the intestinal disease in our patient starts at the time wherein the pubertal pituitary crisis happens. The lack of gonadal counter-regulation following the pubertal pituitary crisis leads to an hormonal imbalance with elevated FSH and LH levels. We suppose that this hormonal imbalance can activate immunopathogenic mechanisms related to Crohn's disease.