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Related Experiment Videos

Amiodarone-induced lens opacities.

A J Flach, B J Dolan, B Sudduth

    Archives of Ophthalmology (Chicago, Ill. : 1960)
    |October 1, 1983
    PubMed
    Summary

    Amiodarone hydrochloride, a cardiac drug, can cause asymptomatic anterior subcapsular lens opacities. These visually inconsequential changes were observed in half of patients on moderate to high doses.

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    Ophthalmology·1998

    Area of Science:

    • Ophthalmology
    • Cardiology
    • Pharmacology

    Background:

    • Amiodarone hydrochloride is a benzofurane derivative prescribed for cardiac abnormalities.
    • The drug is known to cause asymptomatic keratopathy.
    • Previous research noted lipid deposits in lens epithelium but not lens opacities.

    Purpose of the Study:

    • To review the occurrence of anterior subcapsular lens opacities in patients using amiodarone hydrochloride.
    • To assess the visual significance of these lens opacities.

    Main Methods:

    • Examination of 14 patients treated with moderate to high doses of amiodarone hydrochloride.
    • Ophthalmic examination focused on identifying lens opacities.

    Main Results:

    • Seven out of 14 patients (50%) exhibited anterior subcapsular lens opacities.
    • The observed lens opacities were visually inconsequential.

    Conclusions:

    • Amiodarone hydrochloride therapy is associated with anterior subcapsular lens opacities.
    • These opacities appear to be asymptomatic and visually insignificant.

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