Experimentally induced susceptibility to audiogenic seizure

By injecting metal ions and pyridoxal-5'-phosphate, we made the normal mouse prone to sound-induced epilepsy. We showed that the levels of glutamate and aspartate in its inferior colliculus were elevated and the concentration of gamma-aminobutyrate was lowered. The time course of audiogenic susceptibility after the treatment was closely mirrored by changes in the concentrations of glutamate, aspartate, and gamma-aminobutyrate in the inferior colliculus.