Turnover of ribosomes in regenerating rat liver

The turnover of ribosomes was studied in regenerating liver and the rates of ribosome degradation in the proliferative (1-5 days) and post-proliferative (6-12 days) phases after partial hepatectomy compared: Ribosome turnover during the first 3 days is slower, the half-life of ribosomes being approximately 300 hr. Ribosome synthesis is markedly activated--39% synthesis rate, which corresponds to 34% accumulation rate per day. The half-life of ribosomes during the second phase is about 107 hr. The rate of synthesis falls down to 19% the net gain of ribosomes being 3% per day.