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Menstrual dysfunction in cystic fibrosis.

L S Neinstein, D Stewart, C I Wang

    Journal of Adolescent Health Care : Official Publication of the Society for Adolescent Medicine
    |September 1, 1983
    PubMed
    Summary
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    Females with cystic fibrosis experience delayed puberty and menstrual irregularities, often linked to lower body weight. Maintaining adequate weight is crucial for normal menstruation in these patients.

    Area of Science:

    • Reproductive Health
    • Pediatric Endocrinology
    • Genetics and Disease

    Background:

    • Cystic Fibrosis (CF) is a genetic disorder affecting multiple organs.
    • Menstrual dysfunction is a recognized complication in females with CF.
    • Factors contributing to this dysfunction require further investigation.

    Purpose of the Study:

    • To analyze factors associated with menstrual dysfunction in females with CF.
    • To compare characteristics of menarchal versus amenorrheic CF patients.
    • To identify key indicators of menstrual irregularities in this population.

    Main Methods:

    • Retrospective chart review of female patients diagnosed with CF.
    • Statistical comparison of demographic and anthropometric data between menarchal and amenorrheic groups.
    Keywords:
    Age FactorsAmenorrheaBiologyBody WeightContraceptive UsageData AnalysisDecision MakingDemographic FactorsDiseasesDysmenorrheaMenarcheMenstruationMenstruation DisordersPhysiologyPopulationPopulation CharacteristicsPsychosocial FactorsPulmonary EffectsReproductionResearch MethodologySex Behavior

    Related Experiment Videos

  • Correlation analysis to determine the relationship between weight and menarche.

    • Main Results:

    • Mean age of menarche was significantly delayed in CF patients (14.4 years) compared to controls (12.9 years).
    • Significant differences observed in age of diagnosis, weight-height index, weight, height, body fat, and weight/height percentiles between amenorrheic and menarchal CF patients.
    • Body weight showed the highest correlation (r=0.59) with menstrual status; 95% of menarchal patients weighed over 82 lbs vs. 75% of amenorrheic patients weighing under 82 lbs.

    Conclusions:

    • Delayed menarche and menstrual irregularities are prevalent in females with CF.
    • Lower body weight is a significant factor associated with amenorrhea in CF patients.
    • Weight management may be critical for achieving normal pubertal development and menstruation in females with CF.