Menstrual delay and dysfunctional uterine bleeding associated with antiprostaglandin therapy for dysmenorrhea

Antiprostaglandin drugs have been found to provide significant relief from dysmenorrhea. Twelve patients taking ibuprofen or mefenamic acid experienced menstrual delay of several days to two weeks and dysfunctional uterine bleeding. Menstruation returned to normal with the next cycle after the cessation of drug use.