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Ventricular fibrillation from diatrizoate with and without chelating agents
Radiology
|August 1, 1978
Insights
Renografin 76% caused more ventricular fibrillation than Hypaque 76% in dogs. This suggests chelating agents in contrast media may increase toxicity during coronary angiography.
Area of Science:
- Cardiology
- Toxicology
- Radiology
Background:
- Coronary angiography uses contrast media to visualize heart arteries.
- The toxicity of different contrast agents is a critical concern for patient safety.
- Renografin and Hypaque are commonly used iodinated contrast media.
Purpose of the Study:
- To compare the toxicity of Renografin 76% and Hypaque 76% in a canine model.
- To investigate the role of chelating agents in contrast-induced cardiotoxicity.
Main Methods:
- Selective injection of Renografin 76% and Hypaque 76% into the right coronary artery of dogs.
- Monitoring for adverse cardiac events, specifically ventricular fibrillation.
Main Results:
- Ventricular fibrillation occurred significantly more frequently with Renografin 76% administration.
- Hypaque 76%, lacking sodium citrate, showed a lower incidence of ventricular fibrillation.
Conclusions:
- The presence of specific chelating agents (sodium citrate, disodium edetate) in Renografin 76% is associated with increased cardiotoxicity.
- Chelating agents may contribute to the toxicity observed during coronary angiography procedures.
Abstract:
The toxicity of Renografin 76% was compared with that of Hypaque 76% by selective injection of each into the right coronary artery of dogs. Renografin contains the chelating agents sodium citrate and disodium edetate, while Hypaque contains calcium disodium edetate and no sodium citrate. Ventricular fibrillation occurred significantly more often with Renografin, suggesting that chelating agents contribute to toxicity in coronary angiography.