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Electrocardiographic changes in lepra reaction.

P B Zawar, R N Chawhan, R M Swami

    Leprosy in India
    |April 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

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    Lepra reactions can cause significant electrocardiographic (E.C.G.) changes, particularly prolonged QTc intervals. These E.C.G. abnormalities suggest potential myocardial involvement in patients with lepra reactions.

    Area of Science:

    • Cardiology
    • Infectious Diseases
    • Medical Diagnostics

    Background:

    • Leprosy, also known as Hansen's disease, can manifest with inflammatory reactions.
    • Lepra reactions may affect various organ systems, including the cardiovascular system.
    • Electrocardiographic (E.C.G.) changes are a potential indicator of cardiac involvement.

    Purpose of the Study:

    • To evaluate the prevalence and types of electrocardiographic (E.C.G.) changes in patients experiencing lepra reactions.
    • To compare E.C.G. parameters between patients with lepra reactions and a healthy control group.
    • To investigate the potential link between E.C.G. abnormalities and myocardial involvement in lepra reactions.

    Main Methods:

    • A cohort of 54 patients with lepra reactions underwent electrocardiographic (E.C.G.) examinations.

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  • E.C.G. findings were analyzed for abnormalities such as QTc interval prolongation, ST-T wave changes, bundle branch block, and ventricular extrasystoles.
  • E.C.G. data from patients were compared with data from 64 healthy adult controls.

    • Main Results:

    • The study identified E.C.G. abnormalities in patients with lepra reactions, including QTc prolongation (44.44%), ST-T changes (16.66%), bundle branch block (3.70%), and ventricular extrasystoles (3.70%).
    • Patients with lepra reactions exhibited a statistically significant longer mean QTc interval (0.44s ± 0.05s) compared to normal adults (0.41s ± 0.03s) (P < 0.01).
    • The observed E.C.G. abnormalities suggest a higher likelihood of myocardial involvement in individuals with lepra reactions.

    Conclusions:

    • Electrocardiographic (E.C.G.) abnormalities are common in patients with lepra reactions.
    • Prolongation of the QTc interval is a significant finding in this patient group.
    • The E.C.G. changes observed in lepra reactions indicate potential myocardial involvement, warranting further cardiovascular assessment.