[Single large-dose preoperative irradiation in breast cancer]

Proceeding from radiobiological data, the TDF concept and a cumulative radiation effect the authors proposed a new variant of preoperative radiotherapy in operable breast cancer patients. Single doses for the breast and axillary-subclavicular zone that were 15 and 12.5 Gy, were determined. Observation over 72 patients showed that single irradiation did not influence the course of operation and the postoperative period. Good functional and short-term results of treatment make it possible to recommend single large fraction preoperative irradiation for trials in special oncological and radiological institutions.