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Studies on flufenamic acid capsules and tablets.

J Akbuğa, S Gülhan, G Bayraktar-Alpmen

    Die Pharmazie
    |July 1, 1983
    PubMed
    Summary
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    This study compared flufenamic acid dissolution rates in tablets and capsules. Additives and manufacturing methods influenced tablet drug release, impacting bioavailability.

    Area of Science:

    • Pharmaceutical Sciences
    • Drug Delivery Systems

    Background:

    • Flufenamic acid is a non-steroidal anti-inflammatory drug (NSAID).
    • Optimizing drug release from solid dosage forms is crucial for therapeutic efficacy.

    Purpose of the Study:

    • To investigate the in vitro dissolution rate of flufenamic acid.
    • To evaluate the impact of common pharmaceutical additives and manufacturing techniques on flufenamic acid release from tablets.
    • To compare the dissolution profiles of manufactured flufenamic acid tablets with commercial capsules.

    Main Methods:

    • Preparation of flufenamic acid tablets using direct compression and wet granulation techniques.
    • Incorporation of various additives: lactose, corn starch, magnesium stearate, sodium lauryl sulphate, Avicel PH 101, and methyl cellulose.

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  • In vitro dissolution rate determination using the rotating basket method (U.S.P. XIX).

    • Main Results:

    • Additives and manufacturing methods significantly influenced the dissolution rate of flufenamic acid from tablets.
    • Dissolution profiles of the prepared tablets varied based on the excipients used and the compression method.
    • Comparison with commercial flufenamic acid capsules provided a benchmark for drug release.

    Conclusions:

    • The choice of excipients and manufacturing process (direct compression vs. wet granulation) critically affects flufenamic acid dissolution from tablets.
    • Formulation development should carefully consider these factors to achieve desired drug release profiles and potential bioavailability.