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Reduced plasma kininogen concentration during sickle cell crisis
Research Communications in Chemical Pathology and Pharmacology
|August 1, 1983
Summary
Patients with sickle cell anemia have lower kininogen plasma levels. These levels decrease further during sickle cell crises, suggesting the kinin system impacts disease presentation.
Area of Science:
- Hematology
- Biochemistry
- Physiology
Background:
- Sickle cell anemia is a genetic blood disorder characterized by abnormal hemoglobin.
- The kinin system is a cascade of plasma proteins involved in inflammation, blood pressure, and pain.
Purpose of the Study:
- To investigate the levels of kininogen, a component of the kinin system, in patients with sickle cell anemia.
- To determine if kininogen levels change during sickle cell crises.
Main Methods:
- Plasma samples were collected from eight patients with sickle cell anemia (SS hemoglobin) and normal control subjects.
- Kininogen levels were measured in plasma samples.
Main Results:
- Patients with sickle cell anemia exhibited significantly lower plasma kininogen levels compared to healthy controls.
- Kininogen levels were further reduced in sickle cell anemia patients experiencing sickle cell crises.
Conclusions:
- Plasma kininogen levels are profoundly affected in individuals with sickle cell anemia.
- The kinin system may play a role in the clinical manifestations and pathophysiology of sickle cell crises.