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Oncogenic genes and human malignancy.

P Lebowitz

    The Yale Journal of Biology and Medicine
    |March 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Oncogenes, similar to those in viruses, are found in vertebrates and may contribute to human cancers. Research shows these genes, particularly the ras family, are involved in tumor development and chromosomal abnormalities in malignancies.

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    Area of Science:

    • Molecular Oncology
    • Genetics
    • Cancer Biology

    Background:

    • Vertebrates possess genes homologous to viral oncogenes.
    • These cellular oncogenes are implicated in human cancer development.

    Purpose of the Study:

    • To explore the role of cellular oncogenes in human malignancy.
    • To identify specific oncogenes involved in various cancers.

    Main Methods:

    • DNA transformation assays using NIH 3T3 mouse fibroblasts.
    • Identification of oncogenes within human tumor DNA.
    • Analysis of chromosomal localizations and breakpoints in malignancies.

    Main Results:

    • Human tumor DNA can transform NIH 3T3 cells.

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  • The ras gene family, related to viral oncogenes, is frequently involved in human carcinomas, sarcomas, and hematological malignancies.
  • Correlations observed between oncogene locations and chromosomal alterations in specific cancers.

    • Conclusions:

    • Cellular oncogenes, especially the ras family, play a significant role in human cancer.
    • Chromosomal abnormalities associated with oncogenes are linked to specific malignancies.
    • Multiple oncogenes may be altered in certain hematological cancers.