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Cardiac involvement in myasthenia gravis
Acta Neurologica Scandinavica
|August 1, 1983
Summary
Myasthenia gravis (MG) patients may experience myocardial involvement. Abnormalities in left ventricular function, assessed by systolic time intervals, were observed in some patients and improved with neostigmine treatment.
Area of Science:
- Cardiology
- Neurology
- Myology
Background:
- Myasthenia gravis (MG) is associated with non-specific ECG and myocardial histological changes.
- The extent of cardiac involvement in MG is not fully understood.
Purpose of the Study:
- To assess left ventricular function in myasthenia gravis patients using systolic time intervals (STI).
- To investigate potential myocardial involvement in MG.
Main Methods:
- Systolic time intervals (STI) were measured in 10 patients with myasthenia gravis.
- Changes in STI were evaluated before and after neostigmine administration.
Main Results:
- Four out of ten MG patients exhibited abnormal STI.
- These abnormalities normalized after neostigmine injection, suggesting a reversible cardiac dysfunction.
Conclusions:
- Myocardial involvement may be more prevalent in myasthenia gravis than previously recognized.
- Systolic time intervals offer a potential method for assessing cardiac function in MG.