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Related Experiment Videos

CT findings in acute MS.

O Lidegaard, C Gyldensted, M Juhler

    Acta Neurologica Scandinavica
    |August 1, 1983
    PubMed
    Summary

    Unusually large hypodense plaques on CT scans in multiple sclerosis (MS) patients indicate active disease. These lesions, showing blood-brain barrier damage, can mimic other neurological conditions like glioma or infarction.

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    Area of Science:

    • Neurology
    • Radiology
    • Neuroimaging

    Background:

    • Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system.
    • Computed tomography (CT) is a key imaging modality for diagnosing and monitoring MS.
    • Typical CT findings in chronic MS include well-defined hypodense lesions.

    Purpose of the Study:

    • To describe unusual CT findings in active MS plaques.
    • To highlight potential diagnostic challenges posed by these atypical lesions.

    Main Methods:

    • Case series involving 5 patients with definite or highly probable MS.
    • Utilized computerized tomography (CT) scans.
    • Administered intravenous (IV) contrast medium to assess lesion enhancement.

    Main Results:

    • Observed unusually large hypodense plaques in all 5 patients.
    • All active plaques demonstrated enhancement after IV contrast injection.
    • This enhancement suggests blood-brain barrier damage.

    Conclusions:

    • Active MS plaques can present as unusually large hypodense lesions on CT.
    • These atypical findings, indicative of blood-brain barrier damage, may be misdiagnosed as glioma or infarction.
    • Radiologists should consider MS in the differential diagnosis for such lesions.

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