Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Self-poisoning with enteric-coated aspirin.

T C Kwong, J Laczin, J Baum

    American Journal of Clinical Pathology
    |December 1, 1983
    PubMed
    Summary

    Enteric-coated aspirin overdose can delay salicylate absorption, altering drug kinetics. This delayed absorption means standard nomograms may be unreliable for assessing toxicity in such cases.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    From "Husky" to "Bulldog"- behavioural correlates between castration and breed groups in the domestic dog (Canis lupus familiaris).

    BMC veterinary research·2024
    Same author

    CRISPR-based oligo recombineering prioritizes apicomplexan cysteines for drug discovery.

    Nature microbiology·2022
    Same author

    Incremental effects of 28 days of beta-alanine supplementation on high-intensity cycling performance and blood lactate in masters female cyclists.

    Amino acids·2015
    Same author

    NMR studies of clustering in solids.

    Journal of the American Chemical Society·2012
    Same author

    Personal Papers: The honour-not the honorarium.

    British medical journal (Clinical research ed.)·2010
    Same author

    7S and 19S Isoagglutinins in Systemic Lupes Erythematosus.

    Scandinavian journal of rheumatology·2010

    Area of Science:

    • Pharmacology
    • Toxicology
    • Clinical Medicine

    Background:

    • Salicylate toxicity is a common concern in overdose cases.
    • Standard pharmacokinetic models often assume rapid aspirin absorption.
    • Enteric coating is designed to delay drug release and absorption.

    Observation:

    • A case of self-poisoning involving enteric-coated aspirin tablets was documented.
    • Serum salicylate levels showed delayed absorption kinetics compared to immediate-release formulations.
    • The patient's clinical presentation and laboratory values were monitored.

    Findings:

    • Delayed absorption of salicylate from enteric-coated aspirin significantly alters its serum concentration-time profile.
    • The unique kinetics observed challenge the direct applicability of established salicylate nomograms, such as Done's nomogram.
    • Standard nomograms may underestimate the duration or severity of salicylate exposure.

    Implications:

    • Clinical management of enteric-coated aspirin overdose requires careful consideration of delayed absorption.
    • Healthcare providers should be aware that traditional nomograms may not accurately reflect salicylate levels in these cases.
    • Further research into modified nomograms or alternative assessment methods for enteric-coated aspirin toxicity is warranted.

    Related Experiment Videos