Choroidal malignant melanoma in siblings.

Area of Science:

• Ophthalmology
• Oncology
• Genetics

Background:

• Choroidal malignant melanoma is a rare intraocular tumor.
• Familial occurrence of this cancer is exceptionally uncommon.

Observation:

• A 54-year-old male and his 58-year-old sister were diagnosed with choroidal malignant melanoma.
• The brother had a monitored choroidal lesion that rapidly enlarged.
• The sister developed retinal detachment with a pigmented lesion.

Findings:

• Pathologic examination confirmed choroidal malignant melanoma in both siblings.
• Post-enucleation outcomes were favorable for both patients.
• Screening of 18 relatives revealed two benign melanomas (nevi), a rate not exceeding chance.

Implications:

• This case highlights a rare instance of potential familial choroidal melanoma.
• Further research may be needed to explore genetic predispositions.
• Early detection and monitoring are crucial for managing intraocular tumors.