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[Cellular sensitization to fetal antigens during chemical carcinogenesis]
Biomedica Biochimica Acta
|January 1, 1983
Abstract:
Tumor-bearing mice show a cellular sensitization to fetal antigens as detected by the macrophage electrophoretic mobility (MEM) test. Sensitization is independent of etiological and histological tumor factors. An identical state of sensitization can be found after application of chemical carcinogens (N-methyl-N-nitrosourea, benz(a)pyrene or 7,12-dimethylbenz(a)anthracene) before the tumors have developed. The results indicate that the effect is dose-dependent.