Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mast-cell heterogeneity in the rat.

J Damas, J Lecomte

    Experientia
    |November 15, 1983
    PubMed
    Summary

    O-hydroxy ethyl rutoside derivatives trigger histamine and serotonin release from rat skin mast cells, but not peritoneal mast cells. This indicates distinct pharmacological properties between these mast cell populations.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Chemical and biological investigations of a toxic plant from Central Africa, Magnistipula butayei subsp. montana.

    Journal of ethnopharmacology·2005
    Same author

    Proanthocyanidins, from Ribes nigrum leaves, reduce endothelial adhesion molecules ICAM-1 and VCAM-1.

    Journal of inflammation (London, England)·2005
    Same author

    The kallikrein-kinin system, angiotensin converting enzyme inhibitors and insulin sensitivity.

    Diabetes/metabolism research and reviews·2004
    Same author

    [Endothelial acetylcholine].

    Revue medicale de Liege·2002
    Same author

    [Control of cutaneous blood vessels].

    Revue medicale de Liege·2002
    Same author

    Changes in blood glucose and plasma insulin levels induced by bradykinin in anaesthetized rats.

    British journal of pharmacology·2001

    Area of Science:

    • Pharmacology
    • Cell Biology
    • Immunology

    Background:

    • Mast cells are immune cells involved in allergic reactions and inflammation.
    • Different mast cell populations may exhibit unique characteristics and responses.
    • Histamine and serotonin are key mediators released by mast cells.

    Purpose of the Study:

    • To investigate the effect of O-hydroxy ethyl rutoside derivatives on mast cells.
    • To compare the responsiveness of skin mast cells versus peritoneal mast cells to these derivatives.
    • To determine if distinct pharmacological properties exist between these mast cell subsets.

    Main Methods:

    • Rats were used as the animal model.
    • O-hydroxy ethyl rutoside derivatives were administered.
    • Histamine and serotonin release was measured from isolated skin and peritoneal mast cells.

    Main Results:

    • O-hydroxy ethyl rutoside derivatives induced histamine and serotonin release from skin mast cells.
    • No significant release of histamine or serotonin was observed from peritoneal mast cells.
    • This differential response suggests functional heterogeneity between the two mast cell populations.

    Conclusions:

    • Rat skin mast cells and peritoneal mast cells possess different pharmacological properties.
    • O-hydroxy ethyl rutoside derivatives selectively activate skin mast cells, not peritoneal mast cells.
    • Further research is warranted to elucidate the specific mechanisms underlying these observed differences.

    Related Experiment Videos