[Reverse transsynaptic regulation of noradrenaline-H3 uptake in chronic sympathetic denervation]

A change in the functional state of adrenoreceptors in conditions of chronic sympathectomy with guanethidine produces constant spontaneous release of chemical factors regulating the intensity of neuronal uptake of noradrenaline-H3 by an adrenergic neuron. In the first two months when adrenoreceptors experience constant deficit of excitation, the factors are released increasing by half the neuronal uptake of noradrenaline-H3 in atrium and v. deferens. Some increase of NA concentration in peripheral organs during the 3rd month seemingly creates conditions providing for constant activation of sensitized adrenoreceptors which results in the release of factors inhibiting the rate of NA--H3 uptake in atrium by 65%, in v. deferens by 38%. The release from effector cell of chemical agents regulating the intensity of neuronal NA uptake, is one of the local peripheral mechanisms regulating the adrenergic transmitter process.