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Abstract:
Eberle et al. (1981, 1982a) reported diminished proportion of fragile X chromosomes in co-cultures of blood cells taken from fra(X) patients with normal blood cells. However, we did not observe any suppression of fra(X) in the blood of fra(X)-positive patients after co-cultivation with blood of fra(X)-negative subjects. Neither was any suppression caused by medium where fra(X)-negative cells had been previously cultivated for two days.