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Related Experiment Videos

Malignant melanoma and vitiligo-like leukoderma: an electron microscopic study.

H K Koh, A J Sober, H Nakagawa

    Journal of the American Academy of Dermatology
    |November 1, 1983
    PubMed
    Summary

    Widespread leukoderma in melanoma patients may indicate a favorable prognosis. This condition, while resembling vitiligo, presents a broader clinical spectrum and warrants further investigation into associated ocular issues.

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    Area of Science:

    • Dermatology
    • Oncology
    • Ophthalmology

    Background:

    • Melanoma is a serious skin cancer.
    • Leukoderma, or loss of skin pigment, can occur in melanoma patients.
    • The prognostic significance of leukoderma in melanoma is not fully understood.

    Observation:

    • Eight patients with melanoma and widespread leukoderma were studied.
    • Clinical and ultrastructural features of leukoderma were examined.
    • Ocular pigmentary disturbances and uveitis were frequently observed.

    Findings:

    • Leukoderma appears to be a positive prognostic indicator in melanoma.
    • The condition exhibits a varied clinical and ultrastructural spectrum, differing from typical vitiligo.
    • A high incidence of ocular complications was noted in these patients.

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    Implications:

    • Leukoderma may serve as a valuable prognostic marker for melanoma.
    • Further research is needed to understand the link between leukoderma and ocular conditions.
    • Wood's light examination is recommended for monitoring advanced melanoma patients for leukoderma.