[Thioamine compound content in urine determined by using an iodine-azide reagent and selenious acid reaction]

Iodine-azide reagent enabled to evaluate quantitatively content of thioamines excreted within a day. Concentration of thioketons in urine of patients was 11-15 microgram/eqv of thiourea per 1 ml, at the same time their excretion within a day accounted for 13.06 +/- 0.56 mg/eqv in women and 22.11 +/- 1.1 mg/eqv in men. Neither concentration of thioketones in urine nor their excretion in patients with various tumors studied were distinct from these patterns in urine of non-oncologic patients. Comparison of these two methods suggests that development of color on addition of selenous acid to urine is not due to reaction with thioamines present but to interaction with other unknown substances.