[Pathogenesis of hyperlipoproteinemia in rats after the administration of ethanol]

Single administration of ethanol at a dose of 6 g/kg of body weight caused accumulation of triglycerides in rat liver and development of hyperlipoproteinemia. Synthesis of mono-, di-, triglycerides and apoproteins of lipoproteins of very low density was increased in liver tissue. Lipoproteins of very low density were accumulated in blood; their transformation to lipoproteins of low density was impaired and synthesis of high density lipoproteins was decreased. In fatty tissue synthesis of fatty acids was decreased with simultaneous increase in activity of hormone-dependent lipoprotein lipase. Utilization of acetyl CoA pools, formed from exogenous 14C-acetate and 3H-leucine, was dissimilar in synthesis of neutral lipids and phospholipids; the phenomenon demonstrated that acetyl CoA pools were compartmentalized in synthesis of fatty acids.